Asian Journal of Research and Reports in Ophthalmology

Moebius Syndrome: A Case Report on Uncommon Congenital Disorder

Rokhsana Afroze Shoma *

Pediatric Department, Deep Eye Care Foundation, Bangladesh.

Khairul Islam

Training & Research Department, Deep Eye Care Foundation, Bangladesh.

Md Sajidul Huq

Training & Research Department, Deep Eye Care Foundation, Bangladesh.

*Author to whom correspondence should be addressed.

---

Abstract

Moebius syndrome (MBS) is a rare congenital disorder characterized by facial paralysis and limitations in eye movement due to cranial nerve involvement, with potential additional craniofacial and limb abnormalities. We present the case of a two-year-old girl with MBS who presented with watering in both eyes. Clinical examination revealed left-sided facial paralysis, convergent strabismus, and limb malformation. The etiology of MBS remains uncertain, with both genetic and environmental factors implicated. Diagnosis relies on clinical criteria, with supportive care and multidisciplinary management essential for optimizing outcomes. Early rehabilitation is crucial, and interventions may include surgical correction and therapies addressing associated issues. MBS poses significant challenges, necessitating careful evaluation and management strategies to improve patient outcomes and quality of life.

Keywords: Moebius syndrome (MBS), congenital, facial paralysis, cranial nerve palsies

---

---

---

References

Picciolini O, Porro M, Cattaneo E, Castelletti S, Masera G, Mosca F, Bedeschi MF. Moebius syndrome: Clinical features, diagnosis, management and early intervention. Ital J Pediatr. 2016 Jun 3;42(1):56 DOI: 10.1186/s13052-016-0256-5

Sogg RL. Congenital facial diplegia syndrome of möbius: A case report. Arch Ophthalmol. 1961;65(1):16–19 DOI:10.1001/archopht.1961.01840020018004

Souni G, Ayad G, Elouali A, Babakhouya A, Rkain M. Moebius syndrome: A case report on an uncommon congenital syndrome. Cureus. 2023 Jun 21;15(6): e40746 DOI: 10.7759/cureus.40746

Pedersen LK, Maimburg RD, Hertz JM, et al. Moebius sequence –a multidisciplinary clinical approach. Orphanet J Rare Dis. 2017;12(4) Available:https://doi.org/10.1186/s13023-016-0559-z

Pastuszak AL, Schüler L, Speck-Martins CE, et al. Use of misoprostol during pregnancy and Möbius’ syndrome in infants. N Engl J Med. 1998;338(26):1881–5 DOI: 10.1056/NEJM199806253382604

Towfighi J, Marks K, Palmer E, Vannucci R. Möbius syndrome. Neuropathologic observations. Acta Neuropathol. 1979;48 (1):11–7 DOI: 10.1007/BF00691785

Renault F, Sergent B, Charpillet V, Gitiaux C, Vazquez MP. Electromyographic assessment of the temporalis muscle prior to a lengthening myoplasty in patients with Moebius syndrome. Ann Chir Plast Esthet. 2017;62:156–162 DOI: http://dx.doi.org/10.1016/j.anplas.2016.04.007

Hernández JAB, Rojas APC, García ETE. Síndrome de Moebius: manifestaciones neurológicas, musculoesqueléticas y del lenguaje. Repert Med Cir. 2017;26:109–112 Available:https://doi.org/10.1016/j.reper.2017.06.001

Mederos-Mollineda K, Fernández-Vélez Y, Escariz-Borrego L, et al. Síndrome de Moebius: reporte de un caso. Neurol Arg. 2017;9:90–95 Available:https://doi.org/10.1016/j.neuarg.2016.12.004

Gaharu MN, Frederickson S, Natalia M. Moebius syndrome: A case report from Indonesia. Case Rep Int 2022;11:100107Z06MG2022 DOI: 10.5348/100107Z06MG2022CR

Abramson DL, Cohen MM Jr, Mulliken JB. Möbius syndrome: Classification and grading system. Plast Reconstr Surg. 1998 Sep;102(4):961-7 DOI: 10.1097/00006534-199809040-00004

Cuestas G, Quiroga V, Zanetta A, Giménez E. Manejo de la vía aérea en el neonato con síndrome de Moebius [Airway management in the neonate with Moebius syndrome]. An Pediatr (Engl Ed). 201 Oct;91(4):264-267 DOI: 10.1016/j.anpede.2018.11. 017