Ciclosporin Eye Drops in Ocular Graft-Versus-Host Disease: A Case Report
Published: 2024-04-29
Page: 102-106
Issue: 2024 - Volume 7 [Issue 1]
EL Filali EL Mehdi *
Department of Ophthalmology, Cadi Ayyad University, Med Vi University Hospital, Avicenne Military Hospital, Marrakech, Morocco.
Farah Benelkadri
Department of Ophthalmology, Cadi Ayyad University, Med Vi University Hospital, Avicenne Military Hospital, Marrakech, Morocco.
Houssaine Ait Lhaj
Department of Ophthalmology, Cadi Ayyad University, Med Vi University Hospital, Avicenne Military Hospital, Marrakech, Morocco.
Mohamed Kriet
Department of Ophthalmology, Cadi Ayyad University, Med Vi University Hospital, Avicenne Military Hospital, Marrakech, Morocco.
Fouad EL Asri
Department of Ophthalmology, Cadi Ayyad University, Med Vi University Hospital, Avicenne Military Hospital, Marrakech, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Aims: To report a case of severe ocular graft-versus-host disease (GVHD) managed with topical ciclosporin.
Introduction: Ocular graft-versus host disease is a rare and often misdiagnosed aetiology of dry eye syndrome.
Case: We report a case of young women presenting with a severe and bilateral ocular surface inflammation with filamentous keratitis, posterior blepharitis, Meibomian gland dysfunction and neovascular invasion. Ocular GVHD was diagnosed due to severe dry eye symptoms and a history of allogeneic haematopoietic stem cell transplantation. Immunosuppressive treatment resulted in a spectacular anatomical and clinical improvement, rapid resolution of symptoms and improvement in visual acuity.
Conclusion: Ocular GVHD should be considered in any severe dry eye syndrome associated with allogeneic bone marrow transplantation. Topical immunosuppressive therapies have revolutionised the curative management of these patients.
Keywords: Dry eye syndrome, ocular graft-versus-host disease, topical ciclosporin treatment, prevention