A Patient with Multiple Myeloma Presenting with Bilateral Retinal Vein Thrombosis: A Case Report
Asian Journal of Research and Reports in Ophthalmology,
Page 21-26
Abstract
Central retinal vein occlusion is a cause of acute unilateral painless visual loss in the elderly, while bilateral central retinal vein occlusion in a young patient is a rare presentation.
We present a case of a 41-year-old gentleman, without previously identified risk factors, coming with bilateral retinal vein occlusion. His evaluation revealed multiple myeloma with type 1 cryoglobulinaemia as the underlying cause for hypercoagulability.
Our patient’s story illustrates that myeloma should be considered as a differential for bilateral retinal vein occlusion especially when it occurs in the absence of other underlying risk factors.
Keywords:
- Retinal vein occlusion
- multiple myeloma
- cryoglobulinaemia
How to Cite
Perera, M. N. S. K., & Athukoralage, K. U. (2022). A Patient with Multiple Myeloma Presenting with Bilateral Retinal Vein Thrombosis: A Case Report. Asian Journal of Research and Reports in Ophthalmology, 5(3), 21-26. Retrieved from https://journalajrrop.com/index.php/AJRROP/article/view/63
References
Borgman CJ. Concomitant multiple myeloma spectrum diagnosis in a central retinal vein occlusion: A case report and review. Clinical and Experimental Optometry. 2016;99(4):309-12.
Spicka I. Advances in multiple myeloma therapy during two past decades. Comp Struct Biotech J. 2014;10:38–40.
Gozzetti A, Candi V, Papini G, Bocchia M. Therapeutic advancemens in multiple myeloma. Front Oncol. 2014;4:1-5.
Hameed A, Brady JJ, Dowling P, Clynes M, O’Gorman P. Bone disease in multiple myeloma: Pathophysiology and management. Cancer Growth Metastasis. 2014;7:33-42.
Fonseca R, Monge J, Dimopoulos MA. Staging and prognostication of multiple myeloma. Expert Rev Hematol. 2014;7:21-31.
Hayreh SS, Zimmerman B, McCarthy MJ, Podhajsky P. Syatemic diseases associated with various types of retinal vein occlusion. Am J Ophthalol. 2001; 131:61-77.
Rath EZ, Frank RN, Shin DH, Kim C. Risk factors for retinal vein occlusions: A case control study. Ophthalmology. 1992;99: 509-14.
Terrier B, Karras A, Kahn JE, et al. The spectrum of type I cryoglobulinemia vasculitis: New insights based on 64 cases. Medicine (Baltimore). 2013;92(2): 618.
Harel S, Mohr M, Jahn I, et al. Clinico-biological characteristics and treatment of type I monoclonal cryoglobulinaemia: A study of 64 cases. Br J Haematol. 2015; 168(5):671-678
Röllig C, Knop S, Bornhäuser M. Multiple myeloma. Lancet. 2015;385(9983):2197-208.
Riccardi A, Gobbi PG, Ucci G, et al. Changing clinical presentation of multiple myeloma. Eur J Cancer. 1991;27:1401-1405.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, et al. Review of
patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003; 78:21-33.
Rajkumar SV, Dimopoulas MA, Palumbo A, et al. International Myeloma Working Group updated vriteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15: e538.
Ho M, Liu DT, Lam DS, Jonas JB. Retinal vein occlusions, from basics to the latest treatment. Retina. 2016;36(3):432-48.
Wong TY, U. Scott IU. Retinal-Vein Occlusion. N Engl J Med. 363;22:2135-2144.
Barlogie B, Shaughnessy J, Tricot G, et al. Treatment of multiple myeloma. Blood. 2004;103:20-32.
Spicka I. Advances in multiple myeloma therapy during two past decades. Comp Struct Biotech J. 2014;10:38–40.
Gozzetti A, Candi V, Papini G, Bocchia M. Therapeutic advancemens in multiple myeloma. Front Oncol. 2014;4:1-5.
Hameed A, Brady JJ, Dowling P, Clynes M, O’Gorman P. Bone disease in multiple myeloma: Pathophysiology and management. Cancer Growth Metastasis. 2014;7:33-42.
Fonseca R, Monge J, Dimopoulos MA. Staging and prognostication of multiple myeloma. Expert Rev Hematol. 2014;7:21-31.
Hayreh SS, Zimmerman B, McCarthy MJ, Podhajsky P. Syatemic diseases associated with various types of retinal vein occlusion. Am J Ophthalol. 2001; 131:61-77.
Rath EZ, Frank RN, Shin DH, Kim C. Risk factors for retinal vein occlusions: A case control study. Ophthalmology. 1992;99: 509-14.
Terrier B, Karras A, Kahn JE, et al. The spectrum of type I cryoglobulinemia vasculitis: New insights based on 64 cases. Medicine (Baltimore). 2013;92(2): 618.
Harel S, Mohr M, Jahn I, et al. Clinico-biological characteristics and treatment of type I monoclonal cryoglobulinaemia: A study of 64 cases. Br J Haematol. 2015; 168(5):671-678
Röllig C, Knop S, Bornhäuser M. Multiple myeloma. Lancet. 2015;385(9983):2197-208.
Riccardi A, Gobbi PG, Ucci G, et al. Changing clinical presentation of multiple myeloma. Eur J Cancer. 1991;27:1401-1405.
Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, et al. Review of
patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003; 78:21-33.
Rajkumar SV, Dimopoulas MA, Palumbo A, et al. International Myeloma Working Group updated vriteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15: e538.
Ho M, Liu DT, Lam DS, Jonas JB. Retinal vein occlusions, from basics to the latest treatment. Retina. 2016;36(3):432-48.
Wong TY, U. Scott IU. Retinal-Vein Occlusion. N Engl J Med. 363;22:2135-2144.
Barlogie B, Shaughnessy J, Tricot G, et al. Treatment of multiple myeloma. Blood. 2004;103:20-32.
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