Subepithelial Corneal Infiltrates Following Intravitreal Injection of Ranibizumab
Asian Journal of Research and Reports in Ophthalmology,
Page 6-10
Abstract
Purpose: To describe an unusual appearance of corneal subepithelial infiltrates in a patient after receiving intravitreal injection of Ranibizumab.
Methods: 60 years old female patient who has diabetic macular edema received the 1st intravitreal injection of Ranibizumab in her right eye.
Results: The day following the injection the patient presented with discomfort in her right eye, anterior segment examination of the same eye revealed multiple subepithelial marginal corneal infiltrates separated from each other and separated from the limbus by clear zone, no cells or flare in the anterior chamber, she was treated by topical moxifloxacin 0.5% eye drops and dexamethasone eye drops which led to complete resolution of the corneal infiltrates.
Conclusions: Intravitreal Ranibizumab injection may induce immune reaction affecting the cornea in the form of subepithelial infiltrates.
Keywords:
- Corneal infiltrates
- ranibizumab
- intravitreal injection
How to Cite
References
Wykoff CC, Eichenbaum DA, Roth DB, Hill L, Fung AE, Haskova Z. ranibizumab induces regression of diabetic retinopathy in most patients at high risk of progression to proliferative diabetic retinopathy. Ophthalmol Retina. 2018;2:997-1009.
Torres-Costa S, Ramos D, Brandão E, Carneiro Â, Rosas V, Rocha-Sousa A, Falcão-Reis F, Falcão M. Incidence of endophthalmitis after intravitreal injection with and without topical antibiotic prophylaxis. Eur J Ophthalmol. 2021 Mar;31(2):600-606.
Hanna RM, Barsoum M, Arman F, Selamet U, Hasnain H, Kurtz I. Nephrotoxicity induced by intravitreal vascular endothelial growth factor inhibitors: emerging evidence. Kidney Int. 2019 Sep;96(3):572-580.
Bayar SA, Altinors DD, Kucukerdonmez C, et al. Severe corneal changes following intravitreal injection of bevacizumab. Ocul Immunol Inflamm. 2010;18:268–274.
Xu K, Chin EK, Bennett SR. Endophthalmitis after intravitreal injection of vascular endothelial growth factor inhibitors: management and visual outcomes. Ophthalmology. 2018 Aug; 125(8):1279-1286.
Aslan Bayhan S, Bayhan HA, Adam M, Gürdal C Marginal keratitis after intravitreal injection of ranibizumab.Cornea. 2014 Nov;33(11):1238-9.
Dan H. Bourla, Assaf Dotan, Dov Weinberger, et al Consecutive Appearance of Corneal Subepithelial Infiltrates after Intravitreous Bevacizumab Injections. Cornea. 2010;29:686–687.
Ambati BK, Nozaki M, Singh N, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443:993–997.
Boon CJ, Crama N, Klevering BJ, et al. Reflux after intravitreal injection of bevacizumab. Ophthalmology. 2008;115:1270.
Colombres GA, Gramajo AL, Arrambide MP, et al. Delayed corneal epithelial healing after intravitreal bevacizumab: a clinical and experimental study. J Ophthalmic Vis Res. 2011;6:18–25.
-
Abstract View: 29 times
PDF Download: 15 times
