Open Access Case Study

Ocular Manifestation of Ataxia with Isolated Vitamin E Deficiency

Abdi Rhizlane, Chariba Siham, Asmae Maadan, Rachid Sekhsoukh

Asian Journal of Research and Reports in Ophthalmology, Page 1-5

Ataxia with Isolated Vitamin E deficiency (AVED) is an autosomal recessive neurodegenerative disease. The present study reports the case of a 37-year-old patient. Followed since 12 years for Ataxia with Isolated Vitamin E Deficiency, supplemented with vitamin E, stopped for 4 years ago. The ophthalmological examination found a vertical nystagmus, corrected visual acuity at 8/10 to the right and left. Normal anterior segment were seen in both eyes. AVED is clinically characterized by progressive cerebellar ataxia, dysarthria, loss of proprioception and sense of vibration, and the absence of tendon and extensor plantar reflex. Vitamin E prevents lipid oxidation in membranes, is normally present in high concentrations in the photoreceptors of the outer segments in the retina. These results identify abnormalities of the a-TTP gene as a cause of retinitis pigmentosa. Present study emphasizes the importance of serum vitamin E screening in patients with spinocerebellar degeneration resembling Friedreich's ataxia, particularly if the clinical features include retinitis pigmentosa, since this neurological disorder can be arrested by appropriate supplementation with vitamin E.

Open Access Case Study

Lurbinectidin, an Anticancer Drug of Natural Origin, Effectively Reduces Retinal Macular Edema: A Case Report

Feliciana Menna, Filippo Simona, Alessandro Meduri, Stefano Lupo, Francesco Bandello

Asian Journal of Research and Reports in Ophthalmology, Page 24-31

Purpose: To describe a case of macular edema, secondary to thrombosis, reduced during the oral treatment with lurbinectedin.

Methods: Patient affected by central macular edema to the right eye, due to central venous thrombosis, in chemotherapy for a small cell lung cancer with lurbinectidine. Lurbinectidine is a natural marine molecule isolated from the Caribbean algae "Ecteinascidia turbinata", used clinically and approved for the treatment of advanced soft tissue sarcoma. The patient was treated with five chemotherapy sessions of lurbinectidine from October 2018 to May 2019 and we compared the central macular thickness before and after each chemotherapy session and performed OCT progression analysis using the CIRRUS Zeiss software.

Results: A strict cause-effect relationship between therapy and disappearance of edema was noted. We showed an improvement in macular edema in relation to the patient's chemotherapy sessions for therapy of small cell lung cancer.

Discussion: We think that this case demonstrates the anti-edema action of Lurbinectedin in maculopathy without any side effects.

Open Access Case Study

Giant Eyelid Tumor Secondary to T-Cell Lymphoma in a 40 Years Old Woman: A Rare Presentation and Literature Review

Rachid Zerrouk, Mehdi Khmamouche, Adil Elkhoyaali, Zakaria Chaibi, Karim Reda, Abdelbarre Oubaaz

Asian Journal of Research and Reports in Ophthalmology, Page 32-36

Lymphoma is a malignant neoplasm originating from monoclonal B-lymphocytes, T lymphocytes or from natural killer (NK) cells; Lymphoma of the eyelid is defined as lymphoma infiltrating the preseptal tissues, meaning lymphoma infiltrating the skin, subcutaneous tissue and the orbicularis muscle. We report a case of a 40-year-old young woman with a higher eyelid giant tumor with Literature Review.

Open Access Minireview Article

Technique for Measuring Strabismus with Synoptophore – Review

E. Pateras, D. Tzamouranis

Asian Journal of Research and Reports in Ophthalmology, Page 6-12

Binocular vision is a brain process in which the integration of two retinal images into a single visual perception is achieved. Binocular vision provides a greater field of vision as well as the main benefit, stereoscopic vision. For many years, the Synoptophore has been the standard choice instrument for Orthoptic management. It is used for assessing and treating of ocular motility disorders very reliably. Mechanical or electrical irritation of a retina leads to the projection of the sensation to the same point in the space where it would be projected if the same retinal point was irritated by light. This is the instrument that performs a comprehensive assessment of binocular vision. It provides standard measurements and easy treatments. To measure the range of fusion, it is preferable to start with convergence, gradually turning the arm of the Synoptophore inward and asking the patient if he or she sees a cat with a tail and ears. In conclusion its important for ophthalmologist and optometrists to have a good knowledge of handling the instrument and to get used of its worthiness in orthoptic practice. 

Open Access Original Research Article

Determination of Luminance Levels of Visual Acuity Charts in Selected Eye Clinics in Owerri and Their Effects on Vision

E. C. Nkeremuzor, N. C. Ikoro, E. C. Esenwah, C. Nzotta, G. I. Ugwuoke, O. M. Nwaigwe, U. C. Ogbonna

Asian Journal of Research and Reports in Ophthalmology, Page 13-23

Aim: The study on the determination of the luminance levels of visual acuity charts in selected eye clinics in Owerri and their effects on vision, was carried out in 14 eye clinics in Owerri, Imo State.

Study Design: The study design employed in this study was the quantitative type of design, involving the measurement of variables.

Place and Duration of Study: This study was carried out in Owerri, Imo State, Nigeria, between February, 2019 and November, 2019.

Methodology: A total number of 159 young adult volunteers (60 males and 99 females), which summed up to 318 eyes, between the ages of 18 and 35 years, were used for this study. Using a photometer and internally illuminated visual acuity charts, the visual acuity charts’ luminances and visual acuities of the volunteers were measured respectively, under bright ambient examination room illuminations. The t test: two-sample assuming unequal variances statistical method was used to determine if there was a statistical difference in visual acuity, under various visual acuity chart luminance levels.

Results: Visual acuity chart luminance was found not to differ significantly (since p(t<=t)= 0.44 > P = .05)). Fluorescent luminance was found to have no significant effect on right and left eyes’ visual acuities (since p(t<=t)= 7.29 > P = .05)). Tungsten luminance was found to have no significant effect on right and left eyes’ visual acuities (since p(t<=t)= 3.54 > P = .05)).

Conclusion: This study showed that visual acuity was not affected by chart luminance, under bright ambient room illuminations.